Page 1 of 1
Water Content (KF) Method Validation
Posted: Sun Sep 02, 2018 6:11 pm
by tubish81
Hi,
How can I perform method validation of water content with KF? Is there any acceptance critieria for the validation parameters?
Thank you
Re: Water Content (KF) Method Validation
Posted: Sun Sep 02, 2018 6:34 pm
by mattmullaney
Hi Tubish81,
You could consult Mettler-Toledo's white paper "Validation of Titration Methods - A Guideline for Customers", I think it is Applications Brochure 16. It could be that Metrohm has a similar white paper.
Re: Water Content (KF) Method Validation
Posted: Sun Sep 02, 2018 7:45 pm
by tubish81
Thank you MattM:)
I’ll investigate this document.
Re: Water Content (KF) Method Validation
Posted: Mon Sep 03, 2018 12:10 am
by HPLC chemist
The USP also has a separate section on KF titrations and methodology. I can't remember the section number.
Re: Water Content (KF) Method Validation
Posted: Tue Sep 04, 2018 3:54 pm
by dap
European Pharmacopoeia 2.5.12 Suitability.
Re: Water Content (KF) Method Validation
Posted: Wed Sep 05, 2018 6:11 pm
by mattmullaney
Hi Tubish81,
Were you able to find and read the Mettler whitepaper, "Validation of Titration Methods - A Guideline for Customers", Applications Brochure 16?
Re: Water Content (KF) Method Validation
Posted: Thu Sep 06, 2018 4:36 am
by tubish81
Hi Matt,
Thank you so much. I found Mettler whitepaper. I'll write SOP by using the document.
Re: Water Content (KF) Method Validation
Posted: Mon Sep 11, 2023 4:17 am
by kalylcie
Calculate the relative standard deviation (RSD) for both repeatability (intra-day) and intermediate precision (inter-day). Acceptable RSD values depend on your specific application but are typically <2% for both.
among us