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2-Isopropylmalic acid as an internal standard
Posted: Thu Jul 05, 2018 11:30 am
by sriharshabio
Hello,
Any reason why 2-Isopropylmalic acid is widely used as an internal standard in many GC-MS experiments? Thanks.
Harsha
Re: 2-Isopropylmalic acid as an internal standard
Posted: Thu Jul 05, 2018 5:32 pm
by JMB
Two mayor requirements of an IS for any method are,
1) crystallinity
2) stability
Crystallinity enables high purity to be obtained and enables high accuracy to be achieved in preparation of quantitative standards.
Stability means that standards will not degrade quickly.
Regards,
JMB
Re: 2-Isopropylmalic acid as an internal standard
Posted: Wed Aug 08, 2018 10:23 am
by sriharshabio
Thanks JMB