Well, let me turn this around: what would you like to see that does not exist yet?
These may exist, but I'm going to add "low" initial cost to make them less possible, and also make them suitable for using on my current toys.
General criteria:_
1. Cost per analytical column no more than US$1000 in New Zealand.
2. Operating Max Pressure = 300 Bar.
3. Flow Rate 0.1 - 2 ml/min (> 2 = high solvent consumption ).
4. Stable over pH range 1 - 13.
4. Theoretical plates 50,000 / column.
5. Durability 100,000 column volumes of low/high pH mobile phase
6. Low bleed for Mass Spec.
7. Inert ( doesn't degrade sensitive/reactive samples ).
8. Scalable to ( relatively) low cost Preparative
Separation Technology.
1. Set of 3 - 4 chiral columns that separate all enantiomers.
2. GPC columns that cope with high pressure and sample junk.
3. Ion exchange columns that cope with high pressure and sample junk.
4. Set of 4 inert column substrates that can separate of all organics, bioactives, and small molecules, with another set for large molecules..
They can either have specific bonded ligands, or loaded with " ligand du jour" from one mobile phase, rinse, perform separations using simple/cheap/miscible mobile phases, flush ligand, and add another ligand for a different separation.
I'm hoping for 100% water to 100% hydrocarbon via one miscibility-assisting transition solvent. I suspect they may be monolithic, rather than particulate.
I'm sure you'll have them ready for shipment before morning tea
.
Please keep having fun,
Bruce Hamilton
