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Confirmation criteria for an LC MS-MS method

http://www.chromforum.org/viewtopic.php?t=8290

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Confirmation criteria for an LC MS-MS method

Posted: Thu Apr 17, 2008 12:30 pm
by hitelia
Could someone give some ideas what confirmation criteria to use to confirm an analyte screened with an HPLC micromass quattro micro electrospray positve mode.

Confirmation criteria

Posted: Thu Apr 17, 2008 6:14 pm
by MaryCarson
Depends on which regulatory agency you need to satisfy.

Posted: Thu Apr 24, 2008 12:49 am
by Kostas Petritis
I would say that retention time and two MRM transitions that have a constant ratio under the same fragmentation conditons and independantly of analyte concentration should satisfy most of regulatory agencies (having said that I am not knowledgable on the exact requirements of these agencies).
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