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1 1-cyclopropanedicarboxylic acid GC Method
Posted: Fri Feb 23, 2018 4:50 am
by GC@Emmennar
Dear All,
Please help me about 1 1-cyclopropanedicarboxylic acid purity by GC method.
I tried in DB-5, DB-1, ZB-624, AT-5, ZB-1, ZB-WAX Plus capillary columns with different dimensions
but iam not getting peak in above all colmuns
In, Nukol column, peak is getting but peak shape is not good
Re: 1 1-cyclopropanedicarboxylic acid GC Method
Posted: Fri Feb 23, 2018 12:12 pm
by HPLC chemist
We need more information! What are your chromatographic conditions?
Re: 1 1-cyclopropanedicarboxylic acid GC Method
Posted: Sun Feb 25, 2018 3:43 pm
by JI2002
It is not very suitable for direct GC analysis based on its structure and boiling point. Five options:
1. GC following derivatization
2. Hplc
3. IC
4. TITRATION
5. Nmr
Re: 1 1-cyclopropanedicarboxylic acid GC Method
Posted: Mon Feb 26, 2018 1:10 am
by mattmullaney
Hi GC@Emmennar,
I agree with the folks above. Of the GC columns you've tried (assuming you're not performing derivatization, the best choice would be Nukol, or another type of FFAP phase. BP of 1,1-cyclopropane dicarboxylic acid is 371 degrees Celsius, which is very hot...may have trouble eluting 1,1-cyclopropane dicarboxylic acid using an FFAP phase.
Re: 1 1-cyclopropanedicarboxylic acid GC Method
Posted: Mon Feb 26, 2018 3:42 pm
by GOM
As others have suggested, if limited to GC, ideally you do need to be using derivatisation.
Silylation would be my approach and run on DB1 or DB5..
Have you tried this?
Are you comparing your sample with a 97% standard like this from Sigma?
https://www.sigmaaldrich.com/catalog/pr ... ®ion=GB