Struggling for Organotin using HPLC-ICPMS

[kingsemma]

Hello all,

Full of frustration during the method development process of
8 organotins using HPLC-ICPMS, anyone have done such test before?

Two main problems :

1. can those 8 organotins be separated and detected by LC-ICPMS ?
i have read several papaers before and seems that not many people
had done 8 organotins at the same time using LC-ICPMS !

2. Hard to find a condition to keep all 8 organtins stable for test,
e.g. TeBT degrades to TBT easily!


Can anyone give me some advice ?
Have anyone the hand-on experience of LC-ICPMS ?

Thank you and all best wishes for you all !

[jdlh199]

Not much help but I'm working with LC-ICPMS, although I haven't tried organotins yet!

I think it's going to be pretty impossible to get all 8 in the same run and control stability.

Got a GC you can connect to the ICPMS?

[speciation]

GC-ICP-MS is the typical method recommended for organotin, that way, the stability of those organotin will better. LC-ICP-MS will be very difficult. Did you try to use ethylated organotin, I think the stability will be better in ethylated form. But, for organotin, I only have experience in GC-ICP-MS.