Chromatography Forum

Anyone know of examples of 2-methyltetrahydrofuran being used for GPC/HPLC in place of THF?

Any other substitutions for organic solvents such as chloroform and DMF that have been used to make GPC/HPLC more environmentally friendly?

Anyone know of examples of 2-methyltetrahydrofuran being used for GPC/HPLC in place of THF?

I'm not aware of any.

Any other substitutions for organic solvents such as chloroform and DMF that have been used to make GPC/HPLC more environmentally friendly?

THF, DMF, chloroform, etc. can all be "environmentally friendly" if they are recovered for re-use (e.g., by distillation) -- assuming, of course, that one ignores the generation of the required energy. I rather suspect that the consumption of solvents for analytical-scale chromatography is a small fraction of that used in process-scale applications.

For GPC, the choice of solvent is based on four priorities (in this order):
- does the analyte dissolve in it
- can the detector see through it
- is it hazardous
- is it environmentally friendly