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calcium dissolution

http://www.chromforum.org/viewtopic.php?t=802

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calcium dissolution

Posted: Tue Sep 28, 2004 4:21 pm
by Andrea Hilton
I want to perform a dissolution profile for calcium with vitamin D tablets as per USP, but I need to quantify the calcium amount by titration with EDTA. Each tablet has 500 mg of calcium and the volume of dissolution media is 900 mL. Can anyone suggest me a titrimetric method for determination of calcium when I have from 10% to 120% of the labelled amount of calcium dissolved in the dissolution media?

Thanx,

Andrea Hilton

Sorry...

Posted: Tue Sep 28, 2004 4:42 pm
by Andrea Hilton
Or a HPLC method with UV detection...

Thanx,

Andrea

Posted: Wed Sep 29, 2004 3:02 pm
by Bill Tindall
I'm confused. You say you are going to titrate with EDTA. What more information do you need? Filter off undissolved calcium, adjust pH to 10ish with NH3/NH4+, Erichrom Balck T indicatior and away you go. May need a touch of CN- if transition metals are present. Any analytical text will have the details.
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