Chromatography Forum

Hi,
I have one question. We are using Esomeprazole magnesium dihydrate as working standard for analysis of Esomeprazole. The potency of that standard is 94.23 on as is basis . So in calculation we should use Esomeprazole magnesium dihydrate or Esomeprazole magnesium after deducting the water.Can anyone help me in this ?

I would use the potency factor of 94.23 (% w/w ?) to calculate the corrected Esomeprazole magnesium concentration from your original weighing.

"As is" implies that the water content has been accounted for in the potency calculation.


If a purity factor was, for example 99.5% w/w (by HPLC/UV/other method) in the documentation, I would adjust as follows:

(Weight -(Weight x % water content)) x purity

As is" implies that the water content has been accounted for in the potency calculation.
If the meaing of as is basis is we have accounted the water content in potency calculation then what we will do in calculation in on dry basis calculation.