potency of Esomeprazole

[pankajcops]

Hi,
I have one question. We are using Esomeprazole magnesium dihydrate as working standard for analysis of Esomeprazole. The potency of that standard is 94.23 on as is basis . So in calculation we should use Esomeprazole magnesium dihydrate or Esomeprazole magnesium after deducting the water.Can anyone help me in this ?

[JGK]

I would use the potency factor of 94.23 (% w/w ?) to calculate the corrected Esomeprazole magnesium concentration from your original weighing.

"As is" implies that the water content has been accounted for in the potency calculation.


If a purity factor was, for example 99.5% w/w (by HPLC/UV/other method) in the documentation, I would adjust as follows:

(Weight -(Weight x % water content)) x purity

Also, don't post the same question in multiple locations please