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Soduim adduct ions: remedy?

http://www.chromforum.org/viewtopic.php?t=7209

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Soduim adduct ions: remedy?

Posted: Mon Oct 29, 2007 7:46 am
by jbshan
Dear friends,
Am using an ESI ion source for my method and I found that I have problems with Na adduct ions with my parent compound. I have dissoled the compound in 100% methanol and subsequent dilutions in 60% methanol.
How to overcome this problem so that i will get the actual response of the parent compound......URGENT

shan

Posted: Mon Oct 29, 2007 6:24 pm
by sassman
Acid washing of your glassware and anything else that your sample comes in contact with should remove most of the Na contamination. We do this by soaking in 10% nitric acid and then thoroughly rinsing with ultra pure water. Also for your mobile phase use the highest grade water and solvents that you can obtain.
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