Chiral separation of Dexibuprofen from Ibuprofen.

[LCGUY]

Hi Guys,

Do anyone have application of chiral separation of Dexibuprofen [(S)(+)-Ibuprofen] and [(R)(-)-Ibuprofen.



I have a chiral column "alpha-napthyl urea, 250x4.6mm, 5u" of JT Baker (Mallinkrodt Baker). They have given Ibuprofen, naproxen, fenoprofen, amphetamine etc. under application column in their catalogue. Can I use this column for aforesaid separation. Can anyone forward if application on this column if it is there. I just want to avoid spending on new column if my purpose is solved with JT Baker column.

[DR]

Your column vendor would be the best person to check with.

[LCGUY]

Hi DR,
I have sent my query to vendor but still to get any reply on that. I think with so many great chromatographers in this forum, I will get the solution sooner than possible.

I need application on any chiral phase and want to know if this is possible on alpha-Napthyl Urea phase.

I hope my problem will get solved.

[Larry Miller]

Many of the Pirkle type columns are designed for the separation of NSAIDs. I'd guess the Whelk-O would be your best choice. I'd recommend emailing technical support at Regis Technologies (www.registech.com) for additional support. Their online chiral application guide shows the separation of Ibuprofen on page 9.

Larry