Amoxicillin and Clavulanate Potassium

[mondy]

Does somebody have a good hplc method for related substances determination in Amoxicillin and Clavulanate Potassium preparation ?Thank you in advance.

[Kasiban]

Use Waters Atlantis dC18 column
see Waters's 2006-2007 catalog, Page 80

[mondy]

Use Waters Atlantis dC18 column
see Waters's 2006-2007 catalog, Page 80

thank you but....can you be more concrete .What about mobile phase,and the other condition?

[Uwe Neue]

You can get detailed information on applications such as this one on the Waters website: www.waters.com. On top of the screen, click on "Library". On the library page select "Seacrh Applications", next select "Search Chemistry e-Applications". Next you select the first letter of your application from the alphabet, here A for Amoxicillin, where you will find several options. Clicking on the application that you want to see, you will be guided to a pdf-file with a chromatogram and detailed information. If you are a first-time user, you need to sign in, but afterwards the website recognizes you and you can browse at your leasure.

Hope this helps!

[Old_chromatographist]

please try this method for Amoxicllin.

column: C18, mobile phase: 96:4; H2O: acetonitrile.
flow rate 1.5, for 4-mm x 25-cm column.
detector: uv at 230 nm.
STD concentration: about 1.2 mg per mL.

[mondy]

You can get detailed information on applications such as this one on the Waters website: www.waters.com. On top of the screen, click on "Library". On the library page select "Seacrh Applications", next select "Search Chemistry e-Applications". Next you select the first letter of your application from the alphabet, here A for Amoxicillin, where you will find several options. Clicking on the application that you want to see, you will be guided to a pdf-file with a chromatogram and detailed information. If you are a first-time user, you need to sign in, but afterwards the website recognizes you and you can browse at your leasure.

Hope this helps!

thank you it was usefull