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separating impurities in phenol
Posted: Wed Jul 11, 2007 7:12 pm
by phenol guy
I'm having trouble finding the best column to separate cyclohexanol (b.p. 161C), cyclohexanone(b.p. 156C), benzaldehyde (b.p. 178) and anisole (b.p. 154C) from each other in Phenol. The concentrations are very low <10ppm each in molten phenol. The best I can do so far is a supelco wax 10 60 m with a low initial temp then a big push and bakeoff. What do you guys suggest? New customers are great until you get there specifications.
Posted: Wed Jul 11, 2007 7:38 pm
by chromatographer1
I can tell you what won't work well. Anything non-polar.
My quess from the structures is that an intermediate polarity would be the best quess, a 1701 phase or a Vocol, for example.
The main issue with that column is "where would phenol elute?"
Sorry I don't have the data at hand to share with you.
best wishes,
Rod
Posted: Mon Jul 16, 2007 10:12 am
by gcguy
Try a CPsil 13 25mx0.32mmx.2um. We use this column for phenol as an impurity, as as a few other compounds similar to the ones you are interested in.
GCguy
Posted: Mon Jul 16, 2007 2:46 pm
by yaoguocan
have you try HP-5 or some similar colum if not i strongly recomment you to have a try
Posted: Mon Jul 16, 2007 2:49 pm
by chromatographer1
I do not believe a 5% Phenyl column will work.
It requires a more polar column that a 5% phenyl.
Ov-1701 or a OV-225, or a Vocol type column may work.
best wishes,
Rod