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Amoxicillin and Clavulanate Potassium
Posted: Tue Jul 10, 2007 9:07 am
by mondy
Does somebody have a good hplc method for related substances determination in Amoxicillin and Clavulanate Potassium preparation ?Thank you in advance.
Posted: Mon Jul 16, 2007 3:16 am
by Kasiban
Use Waters Atlantis dC18 column
see Waters's 2006-2007 catalog, Page 80
Thank you but....
Posted: Mon Jul 16, 2007 8:27 am
by mondy
Use Waters Atlantis dC18 column
see Waters's 2006-2007 catalog, Page 80
thank you but....can you be more concrete .What about mobile phase,and the other condition?
Posted: Mon Jul 16, 2007 5:05 pm
by Uwe Neue
You can get detailed information on applications such as this one on the Waters website:
www.waters.com. On top of the screen, click on "Library". On the library page select "Seacrh Applications", next select "Search Chemistry e-Applications". Next you select the first letter of your application from the alphabet, here A for Amoxicillin, where you will find several options. Clicking on the application that you want to see, you will be guided to a pdf-file with a chromatogram and detailed information. If you are a first-time user, you need to sign in, but afterwards the website recognizes you and you can browse at your leasure.
Hope this helps!
Re: Amoxicillin and Clavulanate Potassium
Posted: Tue Jul 17, 2007 1:10 pm
by Old_chromatographist
please try this method for Amoxicllin.
column: C18, mobile phase: 96:4; H2O: acetonitrile.
flow rate 1.5, for 4-mm x 25-cm column.
detector: uv at 230 nm.
STD concentration: about 1.2 mg per mL.
Posted: Wed Jul 25, 2007 10:13 am
by mondy
You can get detailed information on applications such as this one on the Waters website:
www.waters.com. On top of the screen, click on "Library". On the library page select "Seacrh Applications", next select "Search Chemistry e-Applications". Next you select the first letter of your application from the alphabet, here A for Amoxicillin, where you will find several options. Clicking on the application that you want to see, you will be guided to a pdf-file with a chromatogram and detailed information. If you are a first-time user, you need to sign in, but afterwards the website recognizes you and you can browse at your leasure.
Hope this helps!
thank you it was usefull