Rimonabant
Posted: Mon Apr 23, 2007 6:56 am
by bookoon
Hi
Have anybody worked on Rimonabant? API or formulation.
My internet search did not yield any good information regarding method of analysis by HPLC.
I am starting on this project very soon. So any help will be great.
Posted: Mon Apr 23, 2007 4:29 pm
by AA
I found 3 references, how much use they will be I cant say, but of course, they each will have a number of references to look at, perhaps one of those references will give you a starting point.
Effects of rimonabant, a selective cannabinoid CB(1) receptor antagonist, in a rat model of Parkinson's disease
Document Type: journal article
Author: Fernandez-Ruiz J;
Source: BRAIN RESEARCH / Year: 2006 / Volume: 1073(;) / Page: 209-219
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Bioisosteric replacements of the pyrazole moiety of rimonabant: Synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB(1) cannabinoid receptor antagonists
Document Type: Journal Article
Author: Lange JHM
Source: JOURNAL OF MEDICINAL CHEMISTRY / Year: 2005 / Volume: 48(6) / Page: 1823-1838
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Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists
Document Type: Journal Article
Author: Lange JHM
Source: JOURNAL OF MEDICINAL CHEMISTRY / Year: 2004 / Volume: 47(3) / Page: 627-643
L