stability of minocycline in extracted samples from plasma
Posted: Sat Mar 24, 2007 9:00 am
friends, i am trying a develop method of assay determination of minocycline in human plasma using LC-MS/MS.
Extraction procedure :SPE
and acidic mobile phase .but here the problem is that the drug response is not stable while the sample were prepare from same sample.it may be any stability issue or unsuitable extrastion procedure.plz... suggest me.
thanks.
Extraction procedure :SPE
and acidic mobile phase .but here the problem is that the drug response is not stable while the sample were prepare from same sample.it may be any stability issue or unsuitable extrastion procedure.plz... suggest me.
thanks.