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hi all
Posted: Fri Mar 09, 2007 6:10 am
by raghunandan
can any one help me in the method development of reltaed substance for escitalopram
Posted: Fri Mar 09, 2007 10:26 am
by Rob Burgess
Its a bit hard to know where to start with this one... you haven't given us much info to go on... (even in the title of your message) try "Googling" it!
hi friends
Posted: Fri Mar 09, 2007 10:31 am
by raghunandan
can any one help me in the method development of ESCITALOPRAM OXALTE RELATED SUBSTANCE
DEAR ROB
Posted: Fri Mar 09, 2007 10:32 am
by raghunandan
PLEASE LET ME KNOW WHAT INFORMATION U WANT
TAHNKS IN ADVANCE
Posted: Mon Mar 12, 2007 7:58 pm
by JA
Hi and welcome to the board. Please check the following useful links:
Please read this
Where to look first!
How do you do method development?
Posted: Mon Mar 12, 2007 9:03 pm
by SIELC_Tech
You probably can use any reverse phase column for this compound:
http://en.wikipedia.org/wiki/Escitalopram
Some of the related impurities can be hydrophilic and not UV active (N,N-dimethylisopropyl fragments), so you might want to use LC/MS first to make sure that you see your impurities.
ACN/water/buffer (phosphate or sulphate for UV) with gradient of ACN from 5% to 70%. For LC/MS use formic acid or ammonium formate with the same gradient. Watch for peak shape due to residual silanol interaction with your amine.