method validation : duloxetine (IS ANYONE LISTENING?????)...

[sanjeev]

i hav still not recieved any answers from your side. I dont kno wat all these guy do that they get answers so quickly. wen i posted my query i guessed it wl be a matter of days but its now more rhan 1.5months and no replies............ i am running short of time

[Bruce Hamilton]

i hav still not recieved any answers from your side. I dont kno wat all these guy do that they get answers so quickly. wen i posted my query i guessed it wl be a matter of days but its now more rhan 1.5months and no replies............ i am running short of time

Well, 1.5 months.... You should pretty much have sorted out the method completely by now - especially as the other thread by Olivia that your first post mentioned had some starting suggestions.

However, just in case you haven't progressed very far, I'd suggest you request the details of the following procedure. You can look at the abstract free on Pubmed, but it doesn't have the chromatography details.

Determination of duloxetine in human plasma via LC/MS and subsequent application to a pharmacokinetic study in healthy Chinese volunteers.
Ma N, Zhang BK, Li HD, Chen BM, Xu P, Wang F, Zhu RH, Feng S, Xiang DX, Zhu YG.
Clin Chim Acta. 2007 Jan 26; [Epub ahead of print]

Bruce Hamilton.

[philippem]

ever searched on the www (google ) ????

type "duloxetine HPLC analysis " and you will have a lot of info
method validation is described in the ICH guidelines

Succes

philippe

[tom jupille]

sanjeev, with all due respect, your original post:
http://www.sepsci.com/chromforum/viewtopic.php?t=5273
is of a type that rarely draws much of a response.

In general, the most (and most useful) responses come when the original post or question includes a fair amount of detail and shows that the poster has one his or her "homework".