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Determination of parabens
Posted: Tue Feb 27, 2007 4:12 am
by sara allen
I try determination of methyl and propyl paraben in gel and placebo has interference. I try columns(C18, C8 & phenyl) with vary phases.
Anybody has an idea for this problem?
Posted: Tue Feb 27, 2007 7:54 pm
by Mark Tracy
That depends a great deal on the nature of the interferences. The possibilities are too many.
Posted: Tue Feb 27, 2007 11:27 pm
by Consumer Products Guy
Why don't you then use GC after trimethylsilyl derivatization? We've done this numerous ways. By HPLC, what we've developed is proprietary, but think other solvents and other columns...but if you've got interferences with both, why not try GC?
Posted: Mon Mar 05, 2007 5:44 am
by sara allen
Thanks for your reply.
I try your Advise.