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Acid buffer for LC/MS analysis of erythromycin

http://www.chromforum.org/viewtopic.php?t=5491

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Acid buffer for LC/MS analysis of erythromycin

Posted: Tue Feb 20, 2007 7:17 am
by Provetech
hi,
I'm developping an LC/MC method to analysis degradation products of erythromycin. I want to use MS Esi compliant buffer, usually TFA 0.1% is used in our lab, but this "buffer" cleaves sugar groupment on the erythromycin. Does anyone knows a volatile buffer i could try to perform the LC/MS analysis ?
Thanks

Posted: Tue Feb 20, 2007 6:02 pm
by Mark Tracy
Try formic or acetic acid.
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