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Acid buffer for LC/MS analysis of erythromycin

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Acid buffer for LC/MS analysis of erythromycin

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Provetech
hi,
I'm developping an LC/MC method to analysis degradation products of erythromycin. I want to use MS Esi compliant buffer, usually TFA 0.1% is used in our lab, but this "buffer" cleaves sugar groupment on the erythromycin. Does anyone knows a volatile buffer i could try to perform the LC/MS analysis ?
Thanks

avatar
Mark Tracy
Try formic or acetic acid.
Mark Tracy
Senior Chemist
Dionex Corp.
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