Detection problm in Ibandronate while preparing with placebo
Posted: Fri Feb 02, 2007 10:20 am
Hi every one
i am facing one problem in ibandronate sodium injection
while i am preparing phosphate(0.5%) phosphite(0.5%) and ibandronate(0.4%) in water i am getting all peaks.
but while i am preparing the same solution with the same limit in placebo i am unable to get any peaks. no response at all in RI detector.
my mobile phase is 1 ml Formic acid in 1 Lit water pH 3.0 with NaOH
Placebo is mixture of Acetic Acid, Sodium Acetate and sodium chlroide
Thanks in advanced
i am facing one problem in ibandronate sodium injection
while i am preparing phosphate(0.5%) phosphite(0.5%) and ibandronate(0.4%) in water i am getting all peaks.
but while i am preparing the same solution with the same limit in placebo i am unable to get any peaks. no response at all in RI detector.
my mobile phase is 1 ml Formic acid in 1 Lit water pH 3.0 with NaOH
Placebo is mixture of Acetic Acid, Sodium Acetate and sodium chlroide
Thanks in advanced