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Caustic /water/organic mix

http://www.chromforum.org/viewtopic.php?t=5207

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Caustic /water/organic mix

Posted: Wed Jan 03, 2007 9:33 pm
by pseudotexan
Is there a column or a precolumn that will hold on to the caustic and allow the water/organic mix to pass? I have not done any LC in quite a few years and have never tried to do anything like this. I am trying to clean the sample and inject it onto a GC as a detector so the caustic is my problem.

Posted: Wed Jan 03, 2007 11:49 pm
by Mark Tracy
It depends on what your compounds of interest are. Are they acidic, basic, zwitterionic or nonionic? Are they hydrophobic or hydrophilic? Is it the organic solvent itself?
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