Caustic /water/organic mix

[pseudotexan]

Is there a column or a precolumn that will hold on to the caustic and allow the water/organic mix to pass? I have not done any LC in quite a few years and have never tried to do anything like this. I am trying to clean the sample and inject it onto a GC as a detector so the caustic is my problem.

[Mark Tracy]

It depends on what your compounds of interest are. Are they acidic, basic, zwitterionic or nonionic? Are they hydrophobic or hydrophilic? Is it the organic solvent itself?