Chromatography Forum

I am very new to the field of chromatography, and have a very limited background in chemistry or chemical engineering.

I am currently conducting my own research on methods of removal of air bubbles in LPLC systems. I have the following questions:

What are some common practice methods to removing the tiny air bubbles in flow, aside from the bubble trap? Do there exist in-line filter housings that can accomplish the removal of air bubbles while also removing particulates? Is an in-line filter a practical method of removing air, why or why not?

Can anybody direct me to viable sources where I can research this topic further?

Thank you.

There are various methods for removing dissolved air in mobile phase , such as helium sparging , ultrasonication , heating and stirring , applying vacuum and using on-line degasser.

If there is air in your mobile phase , in-line filter may worsen the problem , since it makes a resistance to flow , and help to outgas at the suction side.( as a result of partial vacuum formation )

There are various methods for removing dissolved air in mobile phase , such as helium sparging , ultrasonication , heating and stirring , applying vacuum and using on-line degasser.

If there is air in your mobile phase , in-line filter may worsen the problem , since it makes a resistance to flow , and help to outgas at the suction side.( as a result of partial vacuum formation )

Thank you!