Sample Preparation for Dry Syrup

[syx]

Dear members,
Should we reconstitute dry syrup first in order to prepare sample solution? Or - could we weigh the sample powder equivalent to certain volume of syrup?

Regards,
Siswanto

[Bruce Hamilton]

Generally, in the absence of other information, you reconstitute the container of syrup if you are analysing for final product QC and/or regulatory monitoring. Just make sure you receive enough containers for the range of testing.

If you have validated a sampling and analysis procedure that allows you to subsample that specific product or process sample powder, you can subsample.

Syrup powders usually do not remain homogeneous during transport, and others are not homegeneous to start with, hence the need to reconstitute the complete container before analysis.

Bruce Hamilton

[syx]

If we shoud reconstitute it first, what kind of device we could use to transfer the dry syrup from the bottle to volumetric flask? Volume pipette or spoon that is used to deliver the dosage form? Should we rinse that device?

[gbalock]

I would reconstitute the syrup, determine the density of the syrup, then weigh the syrup into the VF. With that you would then be able to determine the volume (dose) of the syrup delivered to the flask.