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ionpairchromatography

http://www.chromforum.org/viewtopic.php?t=4892

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ionpairchromatography

Posted: Fri Nov 03, 2006 3:15 pm
by meudra
Hi everyone,

Does anyone know the fonction off ammoniumnitrate in the next mobile phase:
- ammoniumnitrate and docusate sodium in ACN/water

Is it possible that it is used to increase the polarity off the mobile phase?

Thanks a lot

Posted: Fri Nov 03, 2006 5:01 pm
by Mark Tracy
The ammonium ion competes for the ion-pairing reagent. It is a way to modify the selectivity. Since it works differently than either concentration of ion-pairing reagent or organic solvent, you can move peaks around. I have used sodium sulfate for a similar purpose. I have to say that ammonium nitrate is a strange choice, and I can only guess why that was chosen.
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