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Acetylacetone as mobile pass aditive

http://www.chromforum.org/viewtopic.php?t=48184

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Acetylacetone as mobile pass aditive

Posted: Sat Aug 19, 2017 8:38 am
by Aldijkhuizen
Anyone ever used acetylacetone as mobile phase aditive to avoid tailing?

Re: Acetylacetone as mobile pass aditive

Posted: Sat Aug 19, 2017 10:49 am
by HPLC chemist
Nope. Acetylacetone is used as an akylating agent (if I recall my organic chemistry from >40 years ago). This means it will react with your sample matrix, column, mobile phase...

Re: Acetylacetone as mobile pass aditive

Posted: Sat Aug 19, 2017 11:06 am
by Aldijkhuizen
https://www.ncbi.nlm.nih.gov/pubmed/23643099

Re: Acetylacetone as mobile pass aditive

Posted: Wed Aug 23, 2017 3:49 pm
by Steve Reimer
Acetylacetone is used as a volatile complexing agent. EDTA just won't evaporate.
I don't remember any reactivity issues with it but my experience was limited to metal complex prep.
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