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impurity profile of 1-chlorocarbonyl-4-methyl piperazine HCL

http://www.chromforum.org/viewtopic.php?t=4695

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impurity profile of 1-chlorocarbonyl-4-methyl piperazine HCL

Posted: Wed Oct 04, 2006 1:58 pm
by TT
I am looking for an HPLC /GC method for impurity profile of :
1-chlorocarbonyl-4-methyl piperazine HCL,
It seems like it is becoming degraded very easily in solution. Any ideas regarding what solvent shuold I use to dissolve the sample?

Posted: Wed Oct 04, 2006 5:32 pm
by Mark Tracy
The chlorocarbonyl group is reactive toward water, alcohols, amines, thiols... It is not surprising that you have trouble with stability. You need HPLC conditions that have none of those reactive groups in either the mobile phase or stationary phase. The other way is to let it react with something (Et2NH for example) and measure the derivative.
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