Chromatography Forum

We are looking to purchase a new GC/MS system. Does anyone have any experience / opinions of this system?

I haven't heard a lot... However, the ion source is a "modified" version of the ion source that used to be in Voyager mass spectrometers. And it had notorious problems.

My preference for GC-MS is Varian. The 2100 or 2200 is an economical ion trap MS. They also make single and triple quadrupole systems.

-Aaron

In my opinion the Agilent GCMS is the best one, the new model 5975, have an incredible sensibilty of 175 S/N ratio and the new quick Swap for column change and for aditional info Agilent have the 70% of the GCMS Market the rest of brands have 30% between all of them.

Javier

I tend to disagree about the 5975. It looks great on paper, but I really haven't seen much improvement between our new 5975 and our older 5973. We also have a significantly older Varian 2000 mass spec that outperforms both the Agilent systems. We've been working with trace analysis of dimethylmethyl phosphonate, a nerve agent surrogate. With Agilent's latest and greatest 5975 MSD, we can only detect 1ppm. We've been able to successfully detect 1ppb of the analyte with the Varian system.

We also do a lot of work with explosives and seem to be able to detect 800ppb of TNT with the Agilent, and 10ppb with the Varian.

If sensitivity is what you're going after, hands down I'd recommend the Varian system.

The Clarus 600 GC has the fastest heatup and cooldown rates of any air-bath oven GC. Specialized GC's that heat the column directly can be faster, but require custom columns from the GC manufacturer, and require some significant compromises in sample size, injection technique, etc.

Correcting akthmps, the ion source is not similar to the Voyager, but to the AutoMass. It has undergone several updates since then.

Supplementing jvjkorn's comment, the Clarus 600 MS has a 180:1 detection limit spec for 1 pg of OFN in full scan (only the 2010+ quotes marginally higher, at 185:1), and by far the best PCI and NCI specs.

The "new" quick swap is a late "catch-up" to the Clarus MSVent technology, just as the "new" Agilent â€

The Clarus 600 GC has the fastest heatup and cool down rates of any air-bath oven GC

Does this actually make any difference ? THe Trace and 6890 re fast as I assume is the Shimadzu

Correcting akthmps, the ion source is not similar to the Voyager, but to the AutoMass

Sorry I think you are wrong. The PE system was designed by what is now MicroMass based on original MD800 design specs. The Ion Source is a Micromass "improved" version of the MD800/Voyager ion source. Any resemblance to the Auto Mass source (Delsi Nermag) is most likely related to the original R10-10 being a loose copy of the VG Trio 1. Delsi Nermag were bought by Unicam who were bought by Thermo., there is no direct connection between them and MicroMass.

The "new" quick swap is a late "catch-up" to the Clarus MSVent technology

MS Pre-vent has been available for a long time (10+ years) and was not an MS manufacturer design. It can still be fitted to all MS systems

"new" Agilent â€

Just checked the Thermo specs for the new DSQ II
1 μL of a 1 pg/μL (OFN) in iso-octane will
produce the following minimum signal to
noise for m/z 272 of 200:1 in "Full Scan" EI with the 200/200 pumps
1000:1 in NCI

Ignore the Specs, try the systems, see which software you prefer and judge the service support on your site.
Make the right decsion for you.

Any resemblance to the Auto Mass source (Delsi Nermag) is most likely related to the original R10-10 being a loose copy of the VG Trio 1.

CE Instruments:
I think you got this one backwards. If anything, you would have to say the VG Trio 1 was a lose copy of the R10-10. VG looked at buying RiberMag/Nermag and in the process got a lot of the R10-10 technology. The first VG quads had problems because of a mistake in coping the Riber specs for the pole diameter and the distance between the poles.

I think you got this one backwards.

Possibly, I can only say that when Fisons bought VG and we joined together I was always told the Nermag systems copied the VG. My history of the products runs really from the launch of the MD800

I would go to www.fullspectrum-inc.com
It's a field service company that deals a lot with GC/MS, they are basically the experts at it. Go to their website and give them a call, they will definately answer all of your questions.