Chromatography Forum

Posted: **Sun Sep 17, 2006 3:40 pm**

hi,
i want to know about force degradation of valproate sodium. Is it very stable compound. I have tried 1N HCL, 1 N NaOH, and 3% H2O2 for 12 hrs, but there were no additional peaks found and no reduction in area of drug peak, as well. How can I conduct force degradation of the same.

Posted: **Wed Sep 27, 2006 4:31 pm**

I guess the lack of response is a good indicator, or that this subject fit better "Around the watercooler".

Try to heat with phosphorpentoxide (P2O5)!

Posted: **Wed Sep 27, 2006 7:30 pm**

I would try UV light in the presence of oxygen, or an oxidizing acid aqueous solution. But I don't think it will degrade quickly. Usually these take quite a while to oxidize especially the salts if I remember correctly.

best wishes,

Rod

Posted: **Wed Sep 27, 2006 10:08 pm**

from the structure we know valproate is as stable as rock. Probably this is a case that we try hard but fail to get 10% degradation then report what ever the result.
It does not make sense to me to burn this stuff. Though the previous two suggestions should work if want to burn it.

Chromatography Forum

valproate sodium

valproate sodium

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