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High-throughput HPLC method

http://www.chromforum.org/viewtopic.php?t=4589

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High-throughput HPLC method

Posted: Mon Sep 11, 2006 10:53 am
by yogesh#14
Hi All,

In drug discovery there are lot of compounds synthesized and it becomes difficult to develop HPLC method for eah of the compound. Is there any GENERIC HPLC method for screening of pharmaceutical compounds. Also is there any highthroughput HPLC method for determining Log D and pka of compounds.

Thanks in advance,

Yogesh

Posted: Mon Sep 11, 2006 5:31 pm
by Molly
See the topic on fast screening posted this week.

Posted: Thu Sep 14, 2006 2:38 am
by Uwe Neue
A method has been published by Kaliszan and coworkers for the rapid determination of the pKa via RPLC. You can find his publications on the subject in Analytical Chemistry or in the Journal of Chromatography A.
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