By ylyuen on Friday, August 20, 2004 - 09:02 pm:

Hi! good day.
i'm currently trying to develop a method for glibenclamide and metformin hcl in a gliben/met tablet. i do have individual method for each of the active but they are not applicable as both of them tend to elute out with the same retention time. i know that both of the molecular structure are quite similar and it is difficult to retain both of the active. Do anyone have any suggestion on the method?
TQ!

yenle

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By Ananymous on Saturday, August 21, 2004 - 07:28 am:

hi ylyuen,
i would like to know the seperation method of metformin and its impurity cyanoguanidine on Partisil SCX column.
waitg for ur reply.

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By maris on Sunday, August 22, 2004 - 03:59 am:

Go to corresponding EP monograph, which contains method for the AM impurity.

Good luck