Agilent lcmsd successive SIM monitoring w/o sensitivity loss
Posted: Mon May 29, 2017 11:29 pm
Hi,
I am monitoring three ions which elute at different time points, an internal standard and two ions of interest. In Chemstation, I setup a method which starts monitoring ion 1 from time 0, from time 4 it monitors ion 2, from time 8 it monitors ion 3.
The method works, however, compared to a method that only monitors one of the ions of interest the sensitivity is significantly reduced.
Is there a reason for this behavior?
Thanks,
M
I am monitoring three ions which elute at different time points, an internal standard and two ions of interest. In Chemstation, I setup a method which starts monitoring ion 1 from time 0, from time 4 it monitors ion 2, from time 8 it monitors ion 3.
The method works, however, compared to a method that only monitors one of the ions of interest the sensitivity is significantly reduced.
Is there a reason for this behavior?
Thanks,
M