Fragmentation of adducts in LC/MS [August 19, 2004]
Posted: Sun Aug 29, 2004 7:20 pm
By Drew on Thursday, August 19, 2004 - 01:49 am:
I have observed the following when I was trying to acheive fragmentaion by LC/MS Ion Trap.
The compound I was trying to analyse gave M+H, M+NA and M+H+ACN. However, I found that l can only achieved the fragmentaion of M+H.
Please advice on whether is it possible to obtain fragmentation of M+Na and M+H+ACN by LC/MS ion trap.
-------------------------------------------------------------------------------------------------------
By JF on Thursday, August 19, 2004 - 04:13 am:
Increase the diclustering potential or the collision energy.
-------------------------------------------------------------------------------------------------------
By Bert on Thursday, August 19, 2004 - 04:30 am:
In our (ESP) experience, fragmentation of sodium adducts is most times impossible.
I have observed the following when I was trying to acheive fragmentaion by LC/MS Ion Trap.
The compound I was trying to analyse gave M+H, M+NA and M+H+ACN. However, I found that l can only achieved the fragmentaion of M+H.
Please advice on whether is it possible to obtain fragmentation of M+Na and M+H+ACN by LC/MS ion trap.
-------------------------------------------------------------------------------------------------------
By JF on Thursday, August 19, 2004 - 04:13 am:
Increase the diclustering potential or the collision energy.
-------------------------------------------------------------------------------------------------------
By Bert on Thursday, August 19, 2004 - 04:30 am:
In our (ESP) experience, fragmentation of sodium adducts is most times impossible.