SIM METHOD

[envirogeechem]

Pls. any one can help me in developing SVOC analysis by SIM method

[HPLC chemist]

You can adapt this. I don't see any atoms in common (except Carbon) so I doubt you can remake the wheel and develop a SIM method.

https://www.thermofisher.com/ca/en/home ... lysis.html

[Bigbear]

Look at EPA 525.3.

[James_Ball]

I made a SIM method for the full Appendix 9 VOC list, just used the normal quant ions and qualifier ions from a full scan method, then divided them up into time segments to try and keep it to about 15-17 ions per segment with 10ms dwell times. Use a full scan run to find retention times, then adjust the starting points for each segment from that using the same temperature program. It takes time but it isn't too difficult.