Nitrogen purity in LC-MS/MS

[alcorn]

Hi everybody,

Do anyone know what is the effect of N2 purity (for collision cell) in LC-MS/MS?

I used to N2 99.5% (instead of 99.999% as recommended by the vendor) without any problem. Is it mandatory to switch to higher purity or it may damage my instrument؟

Thanks

[tkubowicz]

Hello

Collision cell gas requires higher purity than the gas used as drying gas.

Please see p.11 in document below:

http://www.ingenieria-analitica.com/dow ... rev_03.pdf

It won't damaged instrument but if you'll have problems with your methods one of the questions could be: what is N2 purity?

Regards

Tomasz Kubowicz