Sample preparation tips for PVP complex with certain APIs
Posted: Tue Feb 28, 2017 5:47 am
Dear All,
Per literature povidone forms molecular adducts in solution with salicylic acid and tannin among others. My compounds of interests have similar functional groups in their stuctures and I cannot release API from the PVP-complex prior HPLC analysis.
Has any of you had similar issues and do you have any tips for developing efficient sample preparation?
Best regards,
JAM
Per literature povidone forms molecular adducts in solution with salicylic acid and tannin among others. My compounds of interests have similar functional groups in their stuctures and I cannot release API from the PVP-complex prior HPLC analysis.
Has any of you had similar issues and do you have any tips for developing efficient sample preparation?
Best regards,
JAM