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Recommendation for TOF system
Posted: Wed May 17, 2006 5:52 am
by sindhu
I am interested to buy an TOF system. My applications is natural products identifcation and quantification.
Which TOF system I should buy ?.
Is it from Waters / Sciex / Agilent/Bruker ??. Is there any other vendor whom I can contact ?
Will anyone can help me out .
Your suggestions will highly be appreciated.
Posted: Wed May 17, 2006 7:41 am
by richa_malhotra
it depends on your choice of mass analyzer and budget available.
are you interested in ms technique or ms/ms technique.
if you can clarify i can give you an idea about choosing a vendor.
Posted: Wed May 17, 2006 10:52 pm
by james little
JEOL is another.
Need to make sure that the instrument works well for accurate mass work.
Need to make sure you understand the technology before you buy. Especially with respect to accurate mass determinations/limitations. Instruments are either ADC or TDC types.
I have some information on the bottom part of my web page (accurate mass, bottom half of accurate mass page) about TDC and dead time correction.
http://users.chartertn.net/slittle/
Also see nice article about JEOL ADC approach at:
http://www.selectscience.net/downloads/ ... of_app.pdf
Posted: Thu May 18, 2006 9:47 pm
by Kostas Petritis
I would probably narrow down the selection between Agilent and Waters. The Agilent has a little bit better mass accuracy, the Waters Q-TOF (although I am not very familiar with the details) has a pseudo-MRM that can increase your sensitivity.
I think it would be helpfull if you could tell us if you are interested for MS/MS capabilities or not. There is about a 2 fold premium for the MS/MS capabilities...
Posted: Tue May 23, 2006 12:39 pm
by sindhu
Thanks for your suggestions.
I am looking for MS/MS system only for my applications.
Can I buy waters Q-Tof Micro or Agilent ? Please suggest me.
Posted: Wed May 24, 2006 4:01 am
by richa_malhotra
i will recommend you to go for Q-Tof micro from micromass as their lockspray is unique and is very useful for exact mass measurement application. thier source is robust because of it you get maximum sensitivity. also the isolation valve which micromass provide will help you to clean the cone very often without venting the system. even thier resolution also better than other vendors.
off course thier software is user friendly and you can get elemental composition by using thier software.
hope my suggestions make you to feel comfortable to select a right system for your applications.
Posted: Fri May 26, 2006 6:22 am
by Kostas Petritis
I do not think you will find a lot of users of the Agilent Q-TOF as it was just released. I happened to attend a pre-release seminar where the specifications sounded good and I can talk about the mass accuracy as it is the same as their ToF only instrument.
So you may want to ask for a quick demo of both instruments...