CSA chiral method
Posted: Tue Apr 04, 2006 4:53 am
Dear chromatographers,
Is any reference/method for the determination of chiral purity of camphor sulfonic acid (and its enantiomer).
Detection definitely would be a difficulty.
Owing to its polar nature, retention in RPLC and elution in NPLC,is difficult .
Though rotation will give some info',definitely at 0.1% level that may not be suitable............
Hooooooops! Can any one throw some light?
But definitely I need to know the isomer at lower level
Thanx in advance
-Raj
Is any reference/method for the determination of chiral purity of camphor sulfonic acid (and its enantiomer).
Detection definitely would be a difficulty.
Owing to its polar nature, retention in RPLC and elution in NPLC,is difficult .
Though rotation will give some info',definitely at 0.1% level that may not be suitable............
Hooooooops! Can any one throw some light?
But definitely I need to know the isomer at lower level
Thanx in advance
-Raj