I have had a run stop mid analysis due to an error message as detailed in the Subject. I have never seen this message before and don't want to try to re-run before figuring out the problem. This is a robust method that we have run regularly so I wouldn't expect it to fail mid run and no pressure issues where experienced during the run. The error message suggests a detector/data collection issue and the detector used was a Waters 2487(Empower 2). If anyone has had this issue previously please let me know what you think went wrong. Thanks.