External vs Internal calibration

[laucchiun]

When should I know which type of calibration to use? Or what are the difference between these two. Thank you.

[tom jupille]

The short answer is "whenever injection volume or sample workup makes a significant contribution to imprecision". There's a more detailed description in the FAQ, but it's in the LC section:
http://www.lcresources.com/wiki/index.p ... alStandard

[DR]

The short answer is "whenever injection volume or sample workup makes a significant contribution to imprecision"...

It's stime to use an Internal standard.

(cleared it up slightly)

[tom jupille]

Thanks, DR! (it was very late at night).