Chromatography Forum

Hi all,

I can't separate all antibiotics peaks nicely. I wonder if no-valley-to-valley integration allowed.
Also, do topical drugs need degradants to be monitored? Is reporting threshold set same as oral drugs?

Thank you.

I can't separate all antibiotics peaks nicely. I wonder if no-valley-to-valley integration allowed.

Is this a USP procedure ? In general, the way I understand it is that anything that you can validate and document is acceptable. If USP procedures were all "perfect", I wouldn't be as bald as a doorknob these days !!!

Also, do topical drugs need degradants to be monitored? Is reporting threshold set same as oral drugs?

The way I understand this is that the regulations are the same; hopefully current thinking is different. In my own mind topical leave-on and wash-off products should also be considered different...