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anti-oxidant for stabilizing compound?
Posted: Thu Feb 09, 2006 9:54 pm
by dougs
I have a compound that degrades quite fast from oxidation. The diluant is water. Are there any anti-oxidants I can try to use for stabilization?
Regards
DS
Posted: Thu Feb 09, 2006 11:11 pm
by KarenJ
Dougs,
We had good luck adding ascorbic acid to a sample solvent for a compound that was easily oxidized. It's a good anti-oxidant, it's non-toxic, and inexpensive.
Karenj
Posted: Thu Feb 09, 2006 11:50 pm
by dougs
thanks for the info. What kind of concentration may be required? 0.1%? 1%?
Regards
Posted: Thu Feb 09, 2006 11:53 pm
by Bill Tindall
also there are some thio compounds that are very effective. I don' t have my book at hand right now to look up what they are, but look up methods for low levels of acsorbic acid. They involve adding one of these compounds to prevent oxidation. They are very effective and work for all sorts of oxygen sensitive analyses.
Posted: Fri Feb 10, 2006 1:01 am
by Mark Tracy
In addition to ascorbate... Sodium thiosulfate is also useful. People used to use thiodiglycol te preserve samples for amino acid analysis, but that probably was not that effective. Dithiothreitol will keep other thiols in the reduced state. Lowering the pH is effective for some phenolics and thiols. If transition metals are catalyzing the oxidation, you can try EDTA.