Control of Standards in unstable equipment (LC-MS/MS)
Posted: Mon Jun 20, 2016 3:48 pm
LC-MS/MS can be very unstable equipment in signal intensity between days, weeks, months.
Since the stability of standards and solvents can be very human dependent, expiration date alone can be tricky, since it doesnt control how many times:
. the working standard solution was already at room temperature;
. how much time was already left the standard solution open;
. and many other lab incidents we all know about..
In this situations, control charts became more important than expiration dates, but with the signal variation in LC-MS/MS equipment those can be completely irrelevant.
Does anyone have good ideas in how to overcome such difficulty?
Thank you all for your time.
Since the stability of standards and solvents can be very human dependent, expiration date alone can be tricky, since it doesnt control how many times:
. the working standard solution was already at room temperature;
. how much time was already left the standard solution open;
. and many other lab incidents we all know about..
In this situations, control charts became more important than expiration dates, but with the signal variation in LC-MS/MS equipment those can be completely irrelevant.
Does anyone have good ideas in how to overcome such difficulty?
Thank you all for your time.