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ESI needle clogged - Q Exactive

http://www.chromforum.org/viewtopic.php?t=31461

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ESI needle clogged - Q Exactive

Posted: Wed May 18, 2016 8:45 am
by marisilvas
I have been facing clogs in the ESI needle in our Q Exactive quite often. I've done some modifications in the method I am running, like reducing the temperature of the probe from 300 to is 150oC and setting an stand by mode with the mobile phase dripping into the probe in a low flow 0.050mL/min but the issue persists.

I would appreciate any advice in this matter!

Re: ESI needle clogged - Q Exactive

Posted: Thu May 19, 2016 5:40 pm
by JMB
What is composition of mobile phase?
What is concentration of analyze ?
Are there any salts preset ?
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