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ESI needle clogged - Q Exactive

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

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ESI needle clogged - Q Exactive

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marisilvas
I have been facing clogs in the ESI needle in our Q Exactive quite often. I've done some modifications in the method I am running, like reducing the temperature of the probe from 300 to is 150oC and setting an stand by mode with the mobile phase dripping into the probe in a low flow 0.050mL/min but the issue persists.

I would appreciate any advice in this matter!

Re: ESI needle clogged - Q Exactive

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JMB
What is composition of mobile phase?
What is concentration of analyze ?
Are there any salts preset ?
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