Chiral Separation of phenethylamines
Posted: Tue Nov 17, 2015 4:12 am
Hi All,
I have been researching a LC method for the chiral separation of phenethylamine compounds, more specifically methylamphetamine. However, I am really struggling to find a LC solution that provides as good results as just derivatizing on a GC-MS.
Preferentially looking to not have to derivatize (or if so, very simple) and run on a Waters HPLC (LC) system. Is there anyone out there that might be using HPLC to separate amphetamines currently (baseline separation)? Does such a method exist? haha
I have read quite a few published articles and not coming up with any methods that might be appropriate besides a method that utilizes the Chiral Drug (Shiseido®) column, which is just a very expensive column to purchase.
Thanks in advance for any assistance,
I have been researching a LC method for the chiral separation of phenethylamine compounds, more specifically methylamphetamine. However, I am really struggling to find a LC solution that provides as good results as just derivatizing on a GC-MS.
Preferentially looking to not have to derivatize (or if so, very simple) and run on a Waters HPLC (LC) system. Is there anyone out there that might be using HPLC to separate amphetamines currently (baseline separation)? Does such a method exist? haha
I have read quite a few published articles and not coming up with any methods that might be appropriate besides a method that utilizes the Chiral Drug (Shiseido®) column, which is just a very expensive column to purchase.
Thanks in advance for any assistance,