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amine analysis by LC-MS

http://www.chromforum.org/viewtopic.php?t=27489

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amine analysis by LC-MS

Posted: Wed Oct 07, 2015 1:57 pm
by flyingmouth
Hi
I want to analyze some simple aliphatic amines (e.g. ethylamine, diethylamine, triethylamine) by LC-MS without derivatization. Has anyone done this before?
It would be appreciated if you could specify analytic conditions.
Thank you.

Sue

Re: amine analysis by LC-MS

Posted: Wed Oct 07, 2015 6:54 pm
by MSCHemist
I haven't but chloroformate (methyl ethyl or n-propyl) derivatization works very well on amines and all you would need is a GC-FID. There was also a paper on trifluoroacetylacetone to form enamines that also looked pretty simple.

Re: amine analysis by LC-MS

Posted: Thu Oct 08, 2015 6:48 am
by bunnahabhain
Hi
I want to analyze some simple aliphatic amines (e.g. ethylamine, diethylamine, triethylamine) by LC-MS without derivatization. Has anyone done this before?
It would be appreciated if you could specify analytic conditions.
Thank you.
Sue
Have a look at http://www.sielc.com/Compound-Diethanolamine.html. You can replace TFA by ammonium formate.

Jörg
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